Read Handbook of Analysis of Oligonucleotides and Related Products

[Download PDF.Ci5T] Handbook of Analysis of Oligonucleotides and Related Products

[Download PDF.Ci5T] Handbook of Analysis of Oligonucleotides and Related Products

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Book Details :
Published on: 2011-02-23
Released on: 2011-02-23
Original language:

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use.Topics discussed include:Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencingPurity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGECharacterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatographyStructure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm)Approaches for the accurate determination of molar extinction coefficient of oligonucleotidesAccurate determination of assay valuesAssessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metalsStrategies for determining the chemical stability of oligonucleotidesThe use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical developmentGuidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeuticsThis resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings. Introduction to Nucleic Acid Electrophoresis Sigma-Aldrich Introduction. Electrophoresis is a method of separation and purification of macromolecules such as nucleic acids (DNA and RNA) and proteins based on the net charge ... 1 Purity Analysis and Impurities Determination by Reversed ... 4 Handbook of Analysis of Oligonucleotides and Related Products The substitution of the methyl for the more polar silanol dramatically increases the hydrophobicity Industry - Pharmaceutical / Biopharmaceutical Advancing Small Molecule HPLC Analysis. Most pharmaceutical drugs on the market are in the form of small molecules. Small molecules and their metabolites are commonly ... Frequently Asked Questions Sigma-Aldrich Frequently Asked Questions from Germany ... We would recommend using the CAS number (Chemical Abstracts Service registry number) for a chemical as a search term ... Fine chemical - Wikipedia History. The roots of both the term fine chemicals and the emergence of the fine chemical industry as a distinct entity date back to the late 1970s when the ... Diagnostic microbiology - Traditional and Modern Approach Diagnostic microbiology - Traditional and Modern Approach 1. Diagnostic Microbiology Identification of Microbes Dr. Chhaya Sawant Lecture 3 ... Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Ion source - Wikipedia An ion source is a device that creates atomic and molecular ions. Ion sources are used to form ions for mass spectrometers optical emission spectrometers particle ... Home - Springer Featured Book Consequences of Microbial Interactions with Hydrocarbons Oils and Lipids: Production of Fuels and Chemicals Published 2017 New books and journals ... Real-Time PCR [M.Tevfik DORAK] Please use this address next time: dorak.info/genetics/realtime.html ***** MIQE: Minimum Information for Publication of qPCR Experiments (Checklist: XLS ...
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